Fix “Windows cannot access the specified device path or file” error

I copied an exe file from a remote machine to my virtual machine(windows server 2003). And when I try to run or 'run as' I get this strange error "Windows cannot access the specified device path or file." The error also says I dont have permission when I am logged in as administrator!

Solution: Right click exe -> properties and click the 'unblock' button and that is it!